Principal Scientist, Pharmacokinetics

Job Description

Description

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity, and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement, and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

The Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) at Spring House Innovation Park is seeking a highly motivated and experienced Principal Scientist to join the Early Development Vaccines group, with particular focus on developing and running assays in support of Phase I and II trials. The primary role of the successful candidate will be to support and contribute to vaccine analytical strategy, assay development and clinical studies through targeted molecular bioanalytical assays. The successful candidate will be a scientific leader, with a passion for developing assays, have expertise in Molecular Biology Techniques, delivering high quality data, and helping teams choose the right assays for data-driven decision making. A record of accomplishment of successful collaboration while working in cross-functional project teams is expected. The successful candidate will also have responsibility for mentoring, scientific supervision, and training scientists.

Education Minimum Requirement:

• Ph.D. in biochemistry, molecular/cellular biology or equivalent bio-related science with 8+ years of relevant industry experience
• M.S. in biochemistry, molecular/cellular biology or equivalent bio-related science with 10+ years industry related experience
• B.A./B.S. in biochemistry, molecular/cellular biology or equivalent bio-related science with 14+ years of relevant industry experience

Required Experience and Skills:

• 10+ years of experience in Molecular Biology assay development and optimization
• Has in-depth understanding of the drug discovery and/or development process and comprehensive knowledge of the principles and concepts of bioanalytical and/or vaccine clinical testing.
• Strong technical expertise in bioanalytical assay design, development and execution in support of antiviral, antibacterial, and/or vaccine discovery. Has advanced knowledge in molecular biology assays such as DNA and RNA isolation, qPCR, RT-qPCR, NGS, or digital PCR with demonstrated ability to achieve results.
• Candidate must be trained in GxP as it applies to regulated bioanalysis
• Ability to understand and implement applicable regulations regarding the use of pathogens (e. g. virus, bacteria, fungi), human cell and tissue use, laboratory safety, health physics and chemical hazards in research.
• Expertise in troubleshooting experimental design, assay development and data analysis

• Proven ability to lead the development of new, innovative approaches in molecular biology and challenge the status quo including experience in new assay technology evaluation

• Excellent communication, mentoring, influencing and leadership skills
• Established external scientific reputation (e.g. publication record, leadership in consortia, external presentations)

Preferred Experience and Skills:

• Expertise in Next Generation Sequencing, particularly development of analysis pipelines
• Familiar with liquid handlers and other automation platforms for sample preparation and assay process including miniaturization of assay formats

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
No

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
n/a

Job Posting End Date:
04/1/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R340436